Nordihydroguaiaretic Acid Analogues: Their Chemical Synthesis and Biological Activities

Author(s): Qingqi Chen.

Journal Name: Current Topics in Medicinal Chemistry

Volume 9 , Issue 17 , 2009

Become EABM
Become Reviewer

Abstract:

Nordihydroguaiaretic acid is a natural occurring lignan mainly isolated and commercially produced from desert plant, creosote bush (Larrea divaricata Cav. Or Corillea tridentate), which can be widely found in the border zone of southern of USA and northern of Mexico. During past 100 years, extensive research has demonstrated that nordihydroguaiaretic acid and its synthetic analogues are potentially useful in treating diseases related to cancers, diabetes, viral, bacterial infections, and inflammation. Remarkably, terameprocol, a tetra-O-methyl derivative of nordihydroguaiaretic acid, is currently in Phase I/II clinical trials as an anticancer agent. This review deals with the chemical synthesis and bioactivities of nordihydroguaiaretic acid and its structurally-related derivatives, which possess anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities. The review consists of the data reported in over 100 publications.

Keywords: Nordihydroguaiaretic acid, NDGA derivatives, terameprocol, survivin inhibitors, lignan, diarylbutanes, anticancers, anti-HIV

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 9
ISSUE: 17
Year: 2009
Page: [1636 - 1659]
Pages: 24
DOI: 10.2174/156802609789941915
Price: $58

Article Metrics

PDF: 16