NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ
The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
Keywords: Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109
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