Synthesis and Antimicrobial Activities of Some New 3-(Chlorophenylethyl)-, 3-(Chlorophenylethenyl)-Isocoumarins and their Dihydro Derivatives

Author(s): Gul S. Khan, G. Qadeer, Nasim H. Rama, Khalid Mohammed Khan.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 7 , 2009

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Abstract:

The bioactive 3-(chlorophenylethyl)- and 3-(chlorophenylethenyl)-isocoumarins were synthesized by the condensation of simple homophthalic acid with 3-chlorophenylpropionoyl chlorides and chlorocinnamoyl chlorides, respectively. Alkaline hydrolysis of these isocoumarins gave the respective keto-acids. (dl)-3,4-Dihydroisocoumarins were obtained by the reduction of the keto-acids to racemic hydroxyl-acids, followed by cyclodehydration using acetic anhydride. These compounds were tested for their antimicrobial and cytotoxicity (Brine shrimp lethality) bioassay. Bioassay indicated that some compounds show good antimicrobial activities and positive lethality.

Keywords: Isocoumarins, dihydroisocoumarins, synthesis, antimicrobial screening

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2009
Page: [579 - 584]
Pages: 6
DOI: 10.2174/157017809789869528
Price: $65

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