An Efficient Method for One-Pot Reductive Cleavage of Acetals to Primary Alcohols Using a Bimetal Redox Couple CoCl2.6H2O-Zn

Author(s): Kuladip Sarma, Amrit Goswami.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 7 , 2009

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Acyclic or cyclic O,O-acetals and O,S-acetals underwent reductive cleavage to give primary alcohols efficiently on treatment with Zn-CoCl2.6H2O-bimetal redox system in dry tetrahydrofuran at ambient temperature to give good to excellent yields.

Keywords: Alcohols, acetals, bimetal redox system, deprotection, hydroxy ether, reductive cleavage

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Article Details

Year: 2009
Page: [568 - 572]
Pages: 5
DOI: 10.2174/157017809789869456
Price: $65

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