Ligand-Free Cu-Catalyzed Cyanation of Aryl Halides with K4[Fe(CN)6] in Water

Author(s): Yunlai Ren, Shuang Zhao, Xinzhe Tian, Zhifei Liu, Jianji Wang, Weiping Yin.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 7 , 2009

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A simple methodology for Cu-catalyzed cyanation of aryl halides with K4[Fe(CN)6] was developed with water as the solvent in conjunction with ligand-free Cu(OAc)2·H2O as the catalyst. The suggested methodology is applicable to cyanation of a wide range of aryl iodides and activated aryl bromides, and allows the catalyst to be reused six times with a very slight change in the catalytic activity.

Keywords: Cyanation, aryl halide, ligand-free catalyst, water solvent

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Article Details

Year: 2009
Page: [564 - 567]
Pages: 4
DOI: 10.2174/157017809789869573
Price: $65

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