A Practical Approach Towards Synthesis of Octahydroquinazolinone Derivatives in Water

Author(s): Hai-Xia Lin, Xiao-Zhen Xie, Xiao-Hong Wang, Bin He.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 7 , 2009

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Abstract:

A simple, efficient and green procedure has been developed for the synthesis of octahydroquinazolinone derivatives by Biginelli-type three-component cyclocondensation reactions of cyclic β-diketones, aldehydes and (thio)urea with p-TsOH catalysis in water.

Keywords: Octahydroquinazolinone, biginelli reaction, cyclic β-diketones, p-toluenesulfonic acid, synthesis, catalysis

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2009
Page: [557 - 559]
Pages: 3
DOI: 10.2174/157017809789869555
Price: $65

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