A Convenient One Pot Synthesis of 3-Cyano-9-methyl-2-methylthio-4-oxo- 4H- pyrimido[2,1-b] pyrimido [4,5-b] Quinoline and its Reactions with Selected Nucleophiles

Author(s): Sambhaji P. Vartale, Vijay N. Bhosale, Sandeep V. Khansole, Ramdas N. Katapalle.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 7 , 2009

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Abstract:

3-Amino-8-methyl pyrimido [4,5-b] quinoline (1) in N,N-dimethyl formamide (DMF) and anhydrous potassium carbonate reacted with ethyl-2-cyano-3,3-bismethyl thioacrylate 2 to afford novel heterocyclic compound 3- cyano-9-methyl-2-methylthio-4-oxo-4H-pyrimido [4,5-b] quinoline 3. The latter were further reacted with selected N-, Oand C- nucleophiles such as arylamines, substituted phenols, heterylamines and compounds with an active methylene group.

Keywords: One pot synthesis, pyrimido quinoline, ketene dithioacetals, N,N-dimethyl formamide, ring anellation, pyrimidine ring

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2009
Page: [544 - 548]
Pages: 5
DOI: 10.2174/157017809789869537
Price: $65

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