Synthesis of a Novel Heterocyclic System - Pyrimido[5,4:5,6]thiopyrano [2,3-b]indole

Author(s): Jurgis Sudzius, Sigitas Tumkevicius.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 7 , 2009

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Abstract:

An efficient protocol for the synthesis of pyrimido[5,4p:5,6]thiopyrano[2,3-b]indoles by the cyclocondensation of 1,3-dihydro-2H-indole-2-thione with 6-chloropyrimidine-5-carbaldehydes has been developed. 4-Chloro-2- methylthiopyrimido[5,4:5,6]thiopyrano[2,3-b]indole was found to undergo smooth nucleophilic substitution with various nucleophiles to give 4-substituted pyrimido[5,4:5,6]thiopyrano[2,3-b]indoles.

Keywords: indoline-2-thione, pyrimidine-5-carbaldehydes, cyclocondensation, nucleophilic substitution, pyrimido[5',4':5,6] thiopyrano[2,3-b]indoles

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2009
Page: [526 - 528]
Pages: 3
DOI: 10.2174/157017809789869492
Price: $65

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