Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Structure Activity Relationship of Organic Alcohol and Esters for Antidepressant- Like Activity

Author(s): Shahnaz Perveen, Arfa Yasmeen, Muhammad Aitmaud Khan, Ahsana Dar, Rehana Jafri, Amir Ahmed.

Abstract:

The synthesized compounds 1-7 were evaluated for their antidepressant activity, among which 2-phenylethyl alcohol 1 and isoamyl phenylacetate 3 showed 43 % and 37 % reduction in immobility time in mice using forced swim test, thereby, displaying antidepressant- like activity. Compound 1 and 3 were equipotent and both these compounds were 2x effective than the standard drug phenelzine. Considering other esters it appears that a decrease in alkyl chain length or addition of either NO2 or OH groups to the phenyl ring caused a marked decline in the antidepressant-like activity.

Keywords: Alcohol, Esters, Antidepressant, Forced Swim Test

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2010
Page: [14 - 17]
Pages: 4
DOI: 10.2174/157018010789869334