Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design, Synthesis, and Biological Evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Acetylcholinesterase Inhibitors

Author(s): Si-Jie Liu, Liu Yang, Xiao-Guang Liu, Ying Luo, Zi-Jian Cao, David Chi Cheong Wan, Huang-Quan Lin, Chun Hu.

Abstract:

The docking study on a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives with acetylcholinesterase has been demonstrated. The synthesis and characterization of a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were described. All target compounds were evaluated in vitro for the inhibitory activities against AChE via Ellman colorimetric assay. Most of the target compounds possessed anti-acetylcholinesterase activity. The preliminary structure-activity relationships were discussed.

Keywords: Acetylcholinesterase, Inhibitors, Synthesis, Heterocycles, Docking, 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivative

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2010
Page: [5 - 8]
Pages: 4
DOI: 10.2174/157018010789869343