Insights on the Structure of Amyloid Fibrils from Site-Directed Mutagenesis

Author(s): Daniel Henrique do Amaral Correa, Carlos Henrique Inacio Ramos.

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 12 , 2009

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Abstract:

To test the hypothesis that the ability to form ordered β-rich amyloid fibers with identical structures is a generic property of proteins we present a study on the overall structures of fibers formed by apomyoglobin mutants that either stabilize or destabilize the native state or the intermediate. Our results indicate that, at least at the macroscopic level, ordered β-rich amyloid fibers have similar structures.

Keywords: Amyloid fibrils, protein folding, site-directed mutagenesis, intermediate, apomyoglobin

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Article Details

VOLUME: 16
ISSUE: 12
Year: 2009
Page: [1519 - 1525]
Pages: 7
DOI: 10.2174/092986609789839223
Price: $58

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