Title: Crystal Structure of Bucain, a Three-Fingered Toxin from the Venom of the Malayan Krait (Bungarus candidus)
VOLUME: 16 ISSUE: 12
Author(s):M. T. Murakami, R. M. Kini and R. K. Arni
Affiliation:Department of Physics, IBILCE/UNESP, Cristovao Colombo 2265, Sao Jose do Rio Preto, SP, 15054-000, Brazil.
Keywords:Bucain, crystal structure, Bungarus candidus, three-finger α-neurotoxin
Abstract: Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 A resolution and based on the molecular topology and hydrophobicity profile is structurally classified as a three-fingered α-neurotoxin possessing a positively charged AChR-binding site.
