1α ,25(OH)2-Vitamin D3 and 17β-Estradiol: Two Steroid Partners Acting in Skeletal Muscle

Author(s): Claudia Buitrago , Lorena Milanesi , Ana Ronda , Andrea Vasconsuelo , Ricardo Boland .

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 9 , Issue 3 , 2009

Abstract:

1α,25(OH)2-vitamin D3 and 17β-estradiol regulate skeletal muscle cell proliferation, differentiation, apoptosis and contractility through receptor-mediated transcriptional and non-genomic mechanisms. This review focuses on recent advances on signal transduction pathways activated by both steroid hormones. Data are given on the participation of the VDR and ERs (α and β) in activation of MAPKs in muscle cells. Likewise, we describe novel evidence supporting non-classical localizations of the VDR in the plasma membrane and ER β in mitochondria. 1α,25(OH)2D3 promotes DNA synthesis in skeletal muscle cells implicating c-Src/ERK1/2, whereas 17β-estradiol inhibits apoptosis through ERK2 and p38 MAPKs. This study provides basis for the understanding of vitamin D- and estrogen-dependent myopathies.

Keywords: 1α,25(OH)2-vitamin D3, 17β-estradiol, skeletal muscle, MAPK, VDR, ER, signal transduction

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2009
Page: [159 - 168]
Pages: 10
DOI: 10.2174/187152209789760585
Price: $58

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