Resisting the Sun with Vitamin D

Author(s): V. B. Sequeira , K. M. Dixon , R. S. Mason .

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 9 , Issue 3 , 2009

Abstract:

Exposure to ultraviolet radiation is essential for the formation of vitamin D in skin. Importantly, the skin contains all the necessary enzymes to convert the inactive vitamin D into the active hormone, 1α,25 dihydroxyvitamin D (1,25D). The same UVB which produces vitamin D also causes DNA damage. Recent studies have implicated 1,25D in protection against skin carcinogenesis via a reduction in DNA damage and maintenance of immune responses following UVR exposure. Vitamin D compounds have the potential to act as a protective measure against UVR-initiated skin cancer.

Keywords: Ultraviolet radiation, vitamin D, 1α,25 dihydroxyvitamin D, cancer, photoprotection

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2009
Page: [129 - 136]
Pages: 8
DOI: 10.2174/187152209789760549
Price: $58

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