Recent Patents on CNS Drug Discovery

Vincenzo Di Marzo
Istituto di Chimica Biomolecolare (I.C.B.)
Consiglio Nazionale delle Ricerche (C.N.R.)
Via Campi Flegrei 34
Pozzuoli, Napoli 80078
Italy

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New Frontiers in Alcoholism and Addiction Treatment

Author(s): Felice Nava, Andrea Vendramin, Ezio Manzato, Mauro Cibin and Alfio Lucchini

Affiliation: Department of Addiction Medicine, Via Ospedale, 18, 31033 Castelfranco Veneto - Treviso, Italy.

Keywords: Alcoholism, addiction, buprenorphine, methadone, suboxone®, naltrexone, gamma-hydroxybutyrrate, nociceptin peptide receptors, CB1 cannabinoid receptors, dopamine

Abstract:

Drug addiction and alcoholism are behavioural disorders characterized by a profound alteration of several brain circuits induced by chronic drug use. Their treatment is yet based on empiricism and today only few pharmacological strategies are fully effective to control both drug use and relapse. The present paper reviews the most updated pharmacotherapies able to contrast both alcoholism and drug addiction including the new patented drugs and the future therapeutic trends.

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Article Details

VOLUME: 5
ISSUE: 1
Page: [81 - 94]
Pages: 14
DOI: 10.2174/157488910789753567