Recent Patents on CNS Drug Discovery

Vincenzo Di Marzo
Istituto di Chimica Biomolecolare (I.C.B.)
Consiglio Nazionale delle Ricerche (C.N.R.)
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Pozzuoli, Napoli 80078


An Update on Peptide Drugs for Voltage-Gated Calcium Channels

Author(s): Lei Gao

Affiliation: Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104 USA.

Keywords: Voltage-gated calcium channel, peptide drug, toxin, venom, small molecule drug


Voltage-gated calcium channels are one of the major ion channels distributed in the human central nervous system, and mediate an influx of extracellular Ca2+ in response to membrane depolarization. Calcium channels are of particular interest in a broad range of cellular functions including cell proliferation and differentiation, gene expression, neurite outgrowth, transmitter and hormone release, and brain plasticity. The dysfunction of calcium channels is related to a variety of clinical disorders such as migraine, hemiplegia, and epilepsy. Therefore, calcium channels have gained great pharmaceutical interest as a privileged target class for the treatment of a wide range of human diseases. This review will examine the known marketed peptide drugs for calcium channels and address the development of some important patented peptide molecules targeting calcium channels.

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Article Details

Page: [14 - 22]
Pages: 9
DOI: 10.2174/157488910789753558