The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein

Author(s): Qing-Shan Fu, Ai-Xin Song, Su-Xia Li, Hong-Yu Hu.

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 12 , 2009

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Abstract:

Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities.

Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease

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Article Details

VOLUME: 16
ISSUE: 12
Year: 2009
Page: [1442 - 1446]
Pages: 5
DOI: 10.2174/092986609789839386
Price: $58

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