Abstract
In recent years, several classes of biologically active molecules containing the γ-lactone ring, pesticides, plant and fungal growth inhibitors, and antibiotics have been found. Thus the synthesis of substituted dihydrofuran-2(3H) ones is a continuously developing area. Few general synthetic approaches to their stereoselective synthesis with broad structural variety are known. This article reviews the latest developments in the synthesis of γ-butyrolactones. We focus on the ring-closing steps and pay special attention to how different authors obtain the correspondent 4-hydroxycarbonyl compound; an acyclic synthon for the γ-lactone ring.
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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