The In Situ Structural Characterization of the Influenza A Virus Matrix M1 Protein within a Virion

Author(s): Alexander V. Shishkov, Elena N. Bogacheva, Alexey A. Dolgov, Alexey L. Chulichkov, Denis G. Knyazev, Natalia V. Fedorova, Alexander L. Ksenofontov, Larisa V. Kordyukova, Elena V. Lukashina, Vladimir M. Mirsky, Lyudmila A. Baratova.

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 11 , 2009

Abstract:

The first attempt has been made to suggest a model of influenza A virus matrix M1 protein spatial structure and molecule orientation within a virion on the basis of tritium planigraphy data and theoretical prediction results. Limited in situ proteolysis of the intact virions with bromelain and surface plasmon resonance spectroscopy study of the M1 protein interaction with lipid coated surfaces were used for independent confirmation of the proposed model.

Keywords: Influenza A virus, matrix M1 protein, secondary structure prediction, tritium planigraphy, surface plasmon resonance spectroscopy, three-dimensional modeling

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2009
Page: [1407 - 1413]
Pages: 7
DOI: 10.2174/092986609789353682
Price: $58

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