Proteomic Analysis of Mitochondria in Raji Cells Following Exposure to Radiation: Implications for Radiotherapy Response

Author(s): Yujie Jiang , Xin Liu , Xiaosheng Fang , Xin Wang .

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 11 , 2009

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Abstract:

Radioresistance represents a major obstacle to a successful outcome for the treatment of non-Hodgkins lymphoma (NHL). Here we performed a global differential proteome analysis of the mitochondria in Raji cells exposed to radiation. The results showed that 23 differentially expressed proteins were identified. Furthermore, GAPDH, RECQL4, MKI67, and ATAD3B could serve as potential biomarkers of radioresistance.

Keywords: Mitochondria, Comparative proteomics, Raji, Radiation, Biomarker

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2009
Page: [1350 - 1359]
Pages: 10
DOI: 10.2174/092986609789353646
Price: $58

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