Confocal Microscopy Evidence of Prion Protein Fragment hPrP[173-195] Internalization in Rat B104 Neuroblastoma Cell Line

Author(s): Emanuela Urso , Raffaele Acierno , Maria Giulia Lionetto , Antonia Rizzello , Andrea Papa , Trifone Schettino , Michele Maffia .

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 11 , 2009

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Abstract:

The cytotoxicity of hPrP[173-195] prion peptide against a neuroblastoma cell model was found independent of its tendency to aggregate over time. Cytosolic and nuclear inclusions of peptide were highlighted by confocal microscopy, suggesting a role as a transcription factor in activating signal transduction pathways involved in cell toxicity.

Keywords: Prion disease, cellular prion protein (PrPC), helix-2, structural ambivalence, synthetic prion peptides, confocal microscopy

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2009
Page: [1281 - 1290]
Pages: 10
DOI: 10.2174/092986609789353655
Price: $58

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