Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Biological Evaluation of 5,6-Dihydro-benzo[c] acridin-7-ol Derivatives as Anti-Alzheimers Disease Drugs

Author(s): Jinpei Zhou, Xiaowen Hu, Huibin Zhang, Hai Qian, Wenlong Huang, Fan Qi, Yanchun Zhang.


The multifactorial pathogenesis of Alzheimers disease (AD) suggests that drug treatments with two or more mechanisms of action, acting in a complementary manner, could be more efficacious to patients suffering from the disease. In an effort to develop new therapies to treat AD, a series of 5,6-dihydro-benzo[c]acridin-7-ol derivatives (5a-5q) were synthesized and evaluated for their AchE-inhibition and neuron-protection effects. Preliminary biological tests suggested that these compounds exhibited mild AchE-inhibition and commendable neuroprotection activities. Compounds 5m, 5n, 5p had noticeable neuron-protection as compared with tacrine and nimodipine.

Keywords: Alzheimer's disease, Cholinesterase inhibitors, Neuroprotection

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Article Details

Year: 2009
Page: [623 - 628]
Pages: 6
DOI: 10.2174/157018009789353527
Price: $58