Identification of Potential Drug Targets of Leishmania infantum by In-silico Genome Analysis

Title: Identification of Potential Drug Targets of Leishmania infantum by In-silico Genome Analysis

Volume: 6 Issue: 8

Author(s): Neeraj Suthar, Arun Goyal and Vikash Kumar Dubey

Affiliation:

Keywords: Antileishmanial drugs, Visceral leishmaniasis, Drug targets

Abstract: Parasite, Leishmania infantum, is the causative agent of visceral leishmaniasis (kala-azar), a fatal disease, if remains untreated. As it is showing resistance to the currently available drugs, search for new drug targets is essential for novel drug discovery. In-silico analysis of complete genome of Leishmania infantum as well as comparison with human genome and genes available in database of essential gene resulted in identification of 40 genes of Leishmania infantum as potential drug targets. These genes code for proteins that are necessary for the survival of parasite and include Methyl transferase cell division protein, transporter proteins, ribonucleoside hydrolase, regulator proteins and proteins involved in pathogenesis. These genes and gene products are excellent targets for antileishmanial drugs.

Cite this article as:

Suthar Neeraj, Goyal Arun and Dubey Kumar Vikash, Identification of Potential Drug Targets of Leishmania infantum by In-silico Genome Analysis, Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353491