Design, Synthesis and Antiproliferative Activities of Artemisinin Derivatives Containing a Substituted Piperazine

Title: Design, Synthesis and Antiproliferative Activities of Artemisinin Derivatives Containing a Substituted Piperazine

Volume: 6 Issue: 8

Author(s): Xue-Lin Yang, Dan Liu, Wei Wang, Lei Qu, Yong-Kui Jing and Lin-Xiang Zhao

Affiliation:

Keywords: Artemisinin, Synthesis, Leukemia, Growth inhibition, Structure-activity relationship

Abstract: Ten artemisinin derivatives containing a piperazine at C-10 linked with ether or ester were designed and synthesized. All the derivatives have improved antiproliferative activity against cancer cell lines, including multidrug resistance (MDR) phenotypes. Compounds linked with ether are more effective than compounds linked with ester.

Cite this article as:

Yang Xue-Lin, Liu Dan, Wang Wei, Qu Lei, Jing Yong-Kui and Zhao Lin-Xiang, Design, Synthesis and Antiproliferative Activities of Artemisinin Derivatives Containing a Substituted Piperazine, Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353446