Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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H3 Receptor Antagonists: Pharmacophore Modeling and its Implications (Supplementry Material)

Author(s): A. B. Pramod, Sivasish Sindiri, M. Ravi Shashi Nayana, Santhosh Kumar Bairy, Ravi Shekar Ananthula, Ravikumar Muttineni, Madala Srividya, M. Kishore Kumar.

Abstract:

Quantitative 3-D pharmacophore model was generated using 30 chemically diverse H3 receptor antagonists and tested for its productiveness using a large test set. It had 2 hydrogen bond acceptor lipids, 1 positive ionizable and 1 hydrophobic feature. Pharmacophore analysis suggested the structural features required for increased H3 receptor activity.

Keywords: Histamine, H3 receptor, Antagonist, Pharmacophore, Virtual Screening, HypoGen

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2009
Page: [585 - 594]
Pages: 10
DOI: 10.2174/157018009789353428
Price: $58