H3 Receptor Antagonists: Pharmacophore Modeling and its Implications (Supplementry Material)
A. B. Pramod,
M. Ravi Shashi Nayana,
Santhosh Kumar Bairy,
Ravi Shekar Ananthula,
M. Kishore Kumar.
Quantitative 3-D pharmacophore model was generated using 30 chemically diverse H3 receptor antagonists and tested for its productiveness using a large test set. It had 2 hydrogen bond acceptor lipids, 1 positive ionizable and 1 hydrophobic feature. Pharmacophore analysis suggested the structural features required for increased H3 receptor activity.
Keywords: Histamine, H3 receptor, Antagonist, Pharmacophore, Virtual Screening, HypoGen
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