Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors

Author(s): Fei Ma, Ping Guo, Lixun Jiang, Mingsheng Feng, Jingbo Shi, Qizheng Yao.

Abstract:

In this paper, we reported the design, and synthesis of a series of novel pterin derivates i.e. 8a∼f, 9a∼f and 10a∼d. Their inhibitory activity against inducible nitric oxide synthase (iNOS) was evaluated in vitro. It was demonstrated that 4-alkoxypterin derivatives with acylation of 2-amino group showed potent inhibitory activity against iNOS, especially 8c, 8f and 10c.

Keywords: Pterin, Tetrahydrobiopterin, Synthesis, Nitric oxide synthase, Inhibitive activity, In vitro

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 6
ISSUE: 8
Year: 2009
Page: [575 - 578]
Pages: 4
DOI: 10.2174/157018009789353482
Price: $58