Leptin in Non-Autoimmune Inflammation

Author(s): Chunlin Cai, Bevra H. Hahn, Giuseppe Matarese, Antonio La Cava.

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)

Volume 8 , Issue 4 , 2009

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Abstract:

Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behcets disease and endometriosis.

Keywords: Leptin, inflammation, metabolism

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2009
Page: [285 - 291]
Pages: 7
DOI: 10.2174/187152809789352168
Price: $58

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