β -Lactamases- the Threat Renews

Author(s): David M. Livermore .

Journal Name: Current Protein & Peptide Science

Volume 10 , Issue 5 , 2009

Become EABM
Become Reviewer

Abstract:

β-Lactamases are the greatest single source of resistance to β-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new β-lactam analogues are introduced but then select for new β-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM- 1 enzyme and modern oxymino cephalosporins by “extended-spectrum” β-lactamases. Tony Finks work contributed greatly to our understanding of the mechanisms and active site function of β-lactamases and this knowledge now informs the search for new β-lactams and β-lactamase inhibitors.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 10
ISSUE: 5
Year: 2009
Page: [397 - 400]
Pages: 4
DOI: 10.2174/138920309789351994
Price: $58

Article Metrics

PDF: 19