Spin-Lattice Relaxation Time in Drug Discovery and Design

Author(s): Jose Daniel Figueroa-Villar , Luzineide Wanderley Tinoco .

Journal Name: Current Topics in Medicinal Chemistry

Volume 9 , Issue 9 , 2009

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Abstract:

NMR is one of the most powerful techniques for ligand-biomolecule interaction studies and drug screening and design. There are several methods that are strongly used, including chemical shift perturbation (CSP), saturation transfer difference (STD) and diffusion coefficients. However, one of the most useful and easy to apply NMR parameters in medicinal chemistry studies is the spin-lattice relaxation data, which can be employed to investigate the strength and topology of intermolecular interactions, such as drug-drug, drug-protein, drug-DNA, drug-micelle (or vesicle) and biomolecule-biomolecule interactions. This review deals with the newest applications of T1 in different studies of interest for drug design and evaluation.

Keywords: NMR, nuclear relaxation, spin-lattice relaxation time, HTS, CSP, intermolecular interaction, topology of interaction

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Article Details

VOLUME: 9
ISSUE: 9
Year: 2009
Page: [811 - 823]
Pages: 13
DOI: 10.2174/156802609789207082
Price: $58

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