Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence
Florence
Italy

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Which Biomarker is Useful to Evaluate as a Treatment Outcome in Spondyloarthritis?

Author(s): Sang-Hoon Lee, Tae Hwan Kim.

Abstract:

Although the etiology of ankylosing spondylitis is unknown, it is necessary to develop tools for evaluating the patient response to the new therapeutic drugs. AS is mediated by chronic inflammation and characterized by bone destruction and formation. Recently, tumor necrosis factor-alpha (TNF-alpha) blockade has been widely used for treatment of AS, and the patient response is evaluated by examining the levels of various biomarkers such as matrix metalloproteinases (MMPs), interleukins (ILs), and vascular endothelial growth factor (VEGFs). This review discusses the recent studies suggesting candidate biomarkers for evaluation of the response to treatment and the joint remodeling markers.

Keywords: Spondyloarthritis, ankylosing spondylitis, biomarkers, TNF-alpha blockade

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2009
Page: [165 - 168]
Pages: 4
DOI: 10.2174/157339709789208679
Price: $58