Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative

Author(s): Youguang Zheng , Xiaoqing Wu , Min Sun , Liuhai Feng , Mingdong Li , Min Ji .

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 7 , 2009

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Abstract:

A new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative has been designed and synthesized as antitumor agent, which was identified by 1HNMR, 13CNMR, IR, MS and EA. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro, and the target compound crystal structure has been characterized by x-ray crystal analysis.

Keywords: Derivative, Antitumor, Agent, In vitro, Crystal structure, X-ray crystal analysis

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2009
Page: [538 - 541]
Pages: 4
DOI: 10.2174/157018009789108240
Price: $58

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