Synthesis and Biochemical Evaluation of a Range of 2-, 3- and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17α-hydroxylase/17,20-Lyase (P45017α)

Title: Synthesis and Biochemical Evaluation of a Range of 2-, 3- and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17α-hydroxylase/17,20-Lyase (P45017α)

Volume: 6 Issue: 7

Author(s): Sabbir Ahmed, Imran Shahid, Kishore K. Bhatti, Wai-Yee Lee and Caroline P. Owen

Affiliation:

Keywords: Synthesis, Evaluation, Probe, Enzyme, 17α-hydroxylase, 17,20-lyase

Abstract: We report the synthesis and evaluation of a range of 2-, 3- and 4-substituted derivatives of benzyl imidazole as probes of the active site of the enzyme 17α-hydroxylase/17,20-lyase (P45017α). In conclusion, the positioning and nature of the substituent appears to play an important role in the inhibition of this enzyme complex.

Cite this article as:

Ahmed Sabbir, Shahid Imran, Bhatti K. Kishore, Lee Wai-Yee and Owen P. Caroline, Synthesis and Biochemical Evaluation of a Range of 2-, 3- and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17α-hydroxylase/17,20-Lyase (P45017α), Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108295