Synthesis and Biochemical Evaluation of a Range of 2-, 3- and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17α-hydroxylase/17,20-Lyase (P45017α)
Kishore K. Bhatti,
Caroline P. Owen.
We report the synthesis and evaluation of a range of 2-, 3- and 4-substituted derivatives of benzyl imidazole as probes of the active site of the enzyme 17α-hydroxylase/17,20-lyase (P45017α). In conclusion, the positioning and nature of the substituent appears to play an important role in the inhibition of this enzyme complex.
Keywords: Synthesis, Evaluation, Probe, Enzyme, 17α-hydroxylase, 17,20-lyase
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