Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Microwave-Assisted Solvent-Free Synthesis of N-alkyl Benzotriazole Derivatives: Antimicrobial Studies

Author(s): Raghu Ningegowda, C. V. Kavitha, B. S. Priya, S. L. Gaonkar, M. V. Tejesvi, K. S. Rangappa, S. Nanjunda Swamy.

Abstract:

To elucidate further our structural activity relation on the chemistry and antimicrobial activity, a series of novel N-alkylated benzotriazole derivatives bearing pharmaceutically important substituted biphenyl and benzyl halides were synthesized. The synthesized compounds were characterized and tested for in vitro antimicrobial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms. The synthesis has been carried out using microwave irradiation method with solvent and without solvent. The obtained results showed high yields. Interestingly, compounds 2a and 2b showed a two fold increased antibacterial activity than the standard drug tested and the compounds 2d and 2e showed potent antifungal activity than the standard drug tested.

Keywords: Benzotriazole, N-alkylation, Solvent-free, Microwave irradiation, Antimicrobials

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2009
Page: [502 - 507]
Pages: 6
DOI: 10.2174/157018009789108222
Price: $58