Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Microwave-Assisted Solvent-Free Synthesis of N-alkyl Benzotriazole Derivatives: Antimicrobial Studies

Author(s): Raghu Ningegowda, C. V. Kavitha, B. S. Priya, S. L. Gaonkar, M. V. Tejesvi, K. S. Rangappa, S. Nanjunda Swamy.


To elucidate further our structural activity relation on the chemistry and antimicrobial activity, a series of novel N-alkylated benzotriazole derivatives bearing pharmaceutically important substituted biphenyl and benzyl halides were synthesized. The synthesized compounds were characterized and tested for in vitro antimicrobial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms. The synthesis has been carried out using microwave irradiation method with solvent and without solvent. The obtained results showed high yields. Interestingly, compounds 2a and 2b showed a two fold increased antibacterial activity than the standard drug tested and the compounds 2d and 2e showed potent antifungal activity than the standard drug tested.

Keywords: Benzotriazole, N-alkylation, Solvent-free, Microwave irradiation, Antimicrobials

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Article Details

Year: 2009
Page: [502 - 507]
Pages: 6
DOI: 10.2174/157018009789108222
Price: $58