A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders

Author(s): H. Uri Saragovi, Edith Hamel, Adriana Di Polo.

Journal Name: Current Alzheimer Research

Volume 6 , Issue 5 , 2009

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Abstract:

The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimers Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [419 - 423]
Pages: 5
DOI: 10.2174/156720509789207912
Price: $58

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