Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Aminobenzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities

Author(s): Tatyana M. Khomenko, Tatyana G. Tolstikova, Alexey V. Bolkunov, Margarita P. Dolgikh, Alla V. Pavlova, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov.

Abstract:

High anticonvulsive and anxiolytic activities of 8-trifluoromethyl-6-amino-benzopentathiepin 5, which can be synthesized by new simple and effective method, have been found. The transformation of the amino group in compound 5 to the amide group drastically changed the biological activity of the compounds.

Keywords: Substituted benzopentathiepins, Anticonvulsive activity, Anxiolytic activity

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Article Details

VOLUME: 6
ISSUE: 6
Year: 2009
Page: [464 - 467]
Pages: 4
DOI: 10.2174/157018009789057544
Price: $58