8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Aminobenzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities
Tatyana M. Khomenko,
Tatyana G. Tolstikova,
Alexey V. Bolkunov,
Margarita P. Dolgikh,
Alla V. Pavlova,
Dina V. Korchagina,
Konstantin P. Volcho,
Nariman F. Salakhutdinov.
High anticonvulsive and anxiolytic activities of 8-trifluoromethyl-6-amino-benzopentathiepin 5, which can be synthesized by new simple and effective method, have been found. The transformation of the amino group in compound 5 to the amide group drastically changed the biological activity of the compounds.
Keywords: Substituted benzopentathiepins, Anticonvulsive activity, Anxiolytic activity
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