Synthesis and Pharmacological Activity of Thiourea Derivatives of 1,7,8,9-Tetramethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

Title: Synthesis and Pharmacological Activity of Thiourea Derivatives of 1,7,8,9-Tetramethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

Volume: 6 Issue: 6

Author(s): Marta Struga, Jerzy Kossakowski, Anna E. Koziol, Tateusz Lis, Ewa Kedzierska and Sylwia Fidecka

Affiliation:

Keywords: Thiourea derivatives, Pharmacological activity, X-ray analysis

Abstract: A series of new thiourea derivatives of 1,7,8,9-tetramethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. The compound 6 was tested for pharmacological activity on animal central nervous system (CNS). The data suggest that compound 6 significantly interacts with 5-HT2 receptors in the brain. The activities of synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells. Elementary analysis, MS, 1H NMR spectra confirmed the identity of the products. The molecular structure of 12 was determined by an X-ray analysis.

Cite this article as:

Struga Marta, Kossakowski Jerzy, Koziol E. Anna, Lis Tateusz, Kedzierska Ewa and Fidecka Sylwia, Synthesis and Pharmacological Activity of Thiourea Derivatives of 1,7,8,9-Tetramethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione, Letters in Drug Design & Discovery 2009; 6 (6) . https://dx.doi.org/10.2174/157018009789057517