Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5]Bis-1,3-Azole Analogs of Bengazoles

Author(s): Laura Scarone , Jose Fajardo , Jenny Saldana , Laura Dominguez , Pablo Esposito , Sylvia Demastteis , Peter Wipf , Eduardo Manta , Gloria Serra .

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 6 , 2009

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Abstract:

Using different heterocycle formation methodologies (Deoxo-Fluor, DAST, POCl3, TosMIC), [2,5]bis-1,3- azoles were prepared as stable analogs of bengazoles, a family of potent anthelmintic marine natural products. The cytotoxic activity of these heterocycles and their precursors on HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis were evaluated.

Keywords: Bis-1, 3-azoles, Anthelmintic, Cytotoxic, Bengazoles

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Article Details

VOLUME: 6
ISSUE: 6
Year: 2009
Page: [413 - 419]
Pages: 7
DOI: 10.2174/157018009789057553
Price: $58

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