Rho Kinase (ROCK) Inhibitors and Their Application to Inflammatory Disorders

Author(s): Philip V. LoGrasso, Yangbo Feng.

Journal Name: Current Topics in Medicinal Chemistry

Volume 9 , Issue 8 , 2009

Abstract:

Inhibitors of Rho kinase (ROCK) have many potential therapeutic applications. The biological focus of this overview will be on the role of ROCK in inflammatory disorders such as multiple sclerosis and asthma. Many ROCK inhibitors have been described in the primary and patent literature, and a diverse range of chemical scaffolds is beginning to emerge. Some of the structural classes that will be highlighted in this review include: isoquinolines, indazoles, aminofurazans, dihydropyrimidines, aminopyrimidines, benzodioxane carboxamides, benzimidazoles, and chroman amides.

Keywords: Rho-kinase (ROCK), asthma, multiple sclerosis, isoquinoline, indazole, aminofurazans, benzimidazoles, aminopyrimidine, chroman amides

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Article Details

VOLUME: 9
ISSUE: 8
Year: 2009
Page: [704 - 723]
Pages: 20
DOI: 10.2174/156802609789044452
Price: $58

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