Mini-Reviews in Medicinal Chemistry

Back

ABC Transporters as Potential Targets for Modulation of Drug Resistance

Author(s): L. Gatti, G. L. Beretta, G. Cossa, F. Zunino, P. Perego.

Abstract:

ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.

Keywords: ATP binding cassette transporters, antitumor drugs, modulators

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 9
ISSUE: 9
Year: 2009
Page: [1102 - 1112]
Pages: 11
DOI: 10.2174/138955709788922656
Price: $58