Login

Journal Image
Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 9
ISSUE: 9
DOI: 10.2174/138955709788922656      Price:  $58









ABC Transporters as Potential Targets for Modulation of Drug Resistance

img
Author(s): L. Gatti, G. L. Beretta, G. Cossa, F. Zunino and P. Perego
Pages 1102-1112 (11)
Abstract:
ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.
Keywords:
ATP binding cassette transporters, antitumor drugs, modulators
Affiliation:
Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.