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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 16
ISSUE: 8
DOI: 10.2174/092986609788923365      Price:  $58









Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms

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Author(s): Rafael Cisne de Paula, Helena Carla Castro, Carlos Rangel Rodrigues, Paulo Assis Melo and Andre Lopes Fuly
Pages 899-907 (9)
Abstract:
Phospholipases A2 enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA2s including biological and structural features, interaction with binding receptors, inhibitors used on structure- function relationship studies and highlighting the mechanism of action and role of the snake venom PLA2s products, the lysophosphatidylcholine.
Keywords:
Phospholipases A2, snake venom, mechanism of action, inhibitors, lysophosphatidylcholine, binding receptors
Affiliation:
Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense,Niteroi, RJ, Brasil.