Regio- and Stereoselective Ring Opening of Allylic Epoxides

Author(s): Mauro Pineschi, Ferruccio Bertolini, Valeria Di Bussolo, Paolo Crotti.

Journal Name: Current Organic Synthesis

Volume 6 , Issue 3 , 2009

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Abstract:

Three-membered heterocyclic rings offer a powerful combination of reactivity, stability, availability, and atom economy. In fact, the asymmetric ring opening of allylic epoxides with nucleophiles of different kinds, as will be discussed in this Review, offers the possibility of generating valuable chiral non-racemic building blocks in a very simple manner and in a stereodefined fashion.

Keywords: Allylic epoxides, nucleophilic ring opening, heteronucleophiles, carbon nucleophiles, regioselectivity, stereoselectivity, enantioselectivity

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [290 - 324]
Pages: 35
DOI: 10.2174/157017909788921862
Price: $58

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