Control of the Regioselectivity in Palladium(0)-Catalyzed Allylic Alkylation

Author(s): Stephanie Norsikian, Chih-Wei Chang.

Journal Name: Current Organic Synthesis

Volume 6 , Issue 3 , 2009

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Abstract:

Palladium(0)-catalyzed allylation of soft nucleophiles is a powerful synthetic methodology for the construction of carboncarbon or carbon-heteroatom bonds. The possibility of controlling the regioselectivity is one of the most interesting aspects of this chemistry. In this review, the different factors that can affect the regiochemistry of the nucleophilic attack will be discussed.

Keywords: Palladium, allylic substitution, regioselectivity, soft nucleophiles, ligands, steric effects

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [264 - 289]
Pages: 26
DOI: 10.2174/157017909788921880
Price: $58

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