Current Protein & Peptide Science

Ben M. Dunn  
Department of Biochemistry and Molecular Biology University of Florida
College of Medicine, P.O. Box 100245, Gainesville
Florida, FL 32610-0245
USA

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Diverse Roles of GADD45α in Stress Signaling

Author(s): Ming Gao, Ning Guo, Chuanshu Huang and Lun Song

Affiliation: Department of Cellular Immunology, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, P. R. China.

Abstract:

Mammalian cells are prone to tumorigenesis when suffering the genotoxic stresses, and the existence of the tumor suppressors validly decrease this possibility. Gadd45α is one of the growth arrest and DNA damage-inducible (Gadd) 45 gene family members and serves as a stress sensor and tumor suppressor under most stress conditions, which is evidenced by cell cycle arrest, DNA repair, senescence or apoptosis triggered by induction of GADD45α expression. However, some recent reports have challenged this notion by demonstrating the correlation of GADD45α expression to cell survival and even progression of certain tumor cells. Therefore, GADD45?? seems to exert multiple roles in stress signaling and tumor development. Elucidation of the related mechanisms will be helpful for the establishment of novel tumor therapeutic strategy targeting GADD45α.

Keywords: GADD45α, Stress, Tumor suppressor, Tumor progression

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Article Details

VOLUME: 10
ISSUE: 4
Page: [388 - 394]
Pages: 7
DOI: 10.2174/138920309788922216
Price: $58