Solvent-Free Synthesis of 1,3-Diphenyl-5-arylpyrazole Derivatives

Author(s): Ji-Tai Li, Ying Yin, Xian-Tao Meng.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 5 , 2009

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Abstract:

The synthesis of 1,3-diphenyl-5-arylpyrazoles via the reactions of 2,3-epoxy-1-phenyl-3-aryl-1-propanones with phenylhydrazine was carried out in 48-84% yields at 230 °C under solvent-free condition within 1.5 h. This method provides several advantages such as operational simplicity, higher yield and solvent-free.

Keywords: cyclization, 1,3-diphenyl-5-arylpyrazole, synthesis, solvent-free reaction, heterocycles

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [384 - 386]
Pages: 3
DOI: 10.2174/157017809788681383
Price: $58