Regioselective Three-Component Synthesis of Indolylpyrazolo[3,4- b]pyridines Induced by Microwave and under Solvent-Free Conditions

Author(s): Jairo Quiroga, Jorge Trilleras, Ana Isabel Sanchez, Braulio Insuasty, Rodrigo Abonia, Manuel Nogueras, Justo Cobo.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 5 , 2009

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Abstract:

New 4-(1H-indol-3-yl)-6-arylpyrazolo[3,4-b]pyridines 7 have been prepared in a solvent-free three-component reaction induced by microwave from 5-aminopyrazole 1, benzaldehydes 2 and 3-indolyl-3-oxopropanenitrile 5. These compounds were also obtained by means of the reaction of aminopyrazole 1 with benzylidene-derivatives of 3-(1H-indol- 3-yl)-3-oxopropanenitrile 6, prepared in the reaction of 3-(1H-indol-3-yl)-3-oxopropanenitrile and aldehydes.

Keywords: 5-Aminopyrazole, 3-(1H-indol-3-yl)-3-oxopropanenitrile, Benzaldehyde, Indolylpyrazolo[3,4-b]pyridine, Threecomponent reaction, Solvent-free procedure, Microwave

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [381 - 383]
Pages: 3
DOI: 10.2174/157017809788681284
Price: $58

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