Asymmetric α-Amination of Aldehydes and Ketones Catalyzed by tert-Butoxy-L-Proline

Author(s): Ramzi Ait-Youcef, Delphine Kalch, Xavier Moreau, Christine Thomassigny, Christine Greck.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 5 , 2009

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Abstract:

Asymmetric electrophilic α-amination of aldehydes and ketones is described using trans-3-tert-butoxy-Lproline and trans-4-tert-butoxy-L-proline as efficient catalysts. Good yields and high enantioselectivities are obtained working at 0°C or at room temperature with a catalyst loading of only 5 mol%.

Keywords: Electrophilic amination, organocatalysis, tert-butoxyproline, azodicarboxylate, α-hydrazinoalcohol

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [377 - 380]
Pages: 4
DOI: 10.2174/157017809788681293
Price: $58

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