Tandem Generation and Trapping of Furo[3,4-c]isoquinoline Intermediates Leading to the Synthesis of Phenanthridine Ring Systems

Author(s): Gouranga P. Jana , Binay K. Ghorai .

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 5 , 2009

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Abstract:

One pot three component coupling of 3-alkynyl-4-isoquinoline carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of phenanthridine ring system has been investigated. This reaction involves the generation of furo[3,4-c]isoquinolines as transient intermediates, which undergo [4+2] cycloaddition with a dienophile in an inter/intramolecular fashion. In fact, this is the first report of the work on furo[3,4-c]isoquinoline intermediates.

Keywords: Azaisobenzofuran, carbene complexes, chromium, Diels-Alder reaction, phenanthridine

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [372 - 376]
Pages: 5
DOI: 10.2174/157017809788681347
Price: $58

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