Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics | BenthamScience

Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics

Author(s): Yanbing Duan, Jia Yu, Haifeng Liu, Min Ji.

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 5 , 2009

Abstract:

Two hydrolytically activated anthraquinone-diclofenac prodrugs have been designed and synthesized. Both prodrugs show significant binding capability to hydroxyapative (HAP), the major component of bone, and hydrolytically activity in simulation physiological conditions in vitro.

Keywords: Bone-targeting, Anthraquinone, Prodrug, Hydrolytic, Bone affinity, Anti-inflammatory

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [393 - 396]
Pages: 4
DOI: 10.2174/1570180810906050393
Price: $58

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