Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics

Author(s): Yanbing Duan, Jia Yu, Haifeng Liu, Min Ji.

Abstract:

Two hydrolytically activated anthraquinone-diclofenac prodrugs have been designed and synthesized. Both prodrugs show significant binding capability to hydroxyapative (HAP), the major component of bone, and hydrolytically activity in simulation physiological conditions in vitro.

Keywords: Bone-targeting, Anthraquinone, Prodrug, Hydrolytic, Bone affinity, Anti-inflammatory

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [393 - 396]
Pages: 4
DOI: 10.2174/1570180810906050393
Price: $58