Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Schiff Bases of 3-Formylchromones as Antibacterial, Antifungal, and Phytotoxic Agents (Supplementry Table)

Author(s): Khalid Mohammed Khan, Aqeel Ahmad, Nida Ambreen, Afroze Amyn, Shahnaz Perveen, Shakeel Ahmed Khan, Muhammad Iqbal Choudhary.

Abstract:

3-Formylchromone (1), 3-methyl-7-hydroxychromone (2) and Schiff Bases of 3-formylchromone 3-25 have been synthesized and their antibacterial, antifungal and phytotoxic potentials have been evaluated. Thirteen compounds 1- 7, 14, 17-20 and 22 were screened for their antibacterial effects against fourteen Gram positive and sixteen Gram negative bacterial strains using ampicilline as standard drug. Twelve compounds 1-7, 16-18, 21 and 22 were evaluated against fourteen fungal strains. Eighteen compounds 1-4, 6-13, 15, 17, and 23-25 were screened for their phytotoxic potential and showed varying degree of activity. The structures of the synthesized compounds were determined by using spectroscopic techniques including 1H NMR, EIMS, IR and UV. Elemental analysis results were found to be satisfactory.

Keywords: 3-Formylchromone, 3-methyl-7-hydroxychromone, Schiff Bases, Antibacterial, Antifungal, Phytotoxic activity

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2009
Page: [363 - 373]
Pages: 11
DOI: 10.2174/1570180810906050363
Price: $58